Oksykodon jest p\u00f3\u0142syntetycznym morfinopodobnym alkaloidem opioidowym o dzia\u0142aniu przeciwb\u00f3lowym. Oksykodon wywiera swoje dzia\u0142anie przeciwb\u00f3lowe poprzez wi\u0105zanie si\u0119 z receptorami mu w o\u015brodkowym uk\u0142adzie nerwowym (OUN), na\u015bladuj\u0105c w ten spos\u00f3b dzia\u0142anie endogennych opioid\u00f3w. Wi\u0105zanie receptora opiatowego stymuluje wymian\u0119 GTP na PDB w kompleksie bia\u0142ka G i hamuje cyklaz\u0119 adenylanow\u0105, zapobiegaj\u0105c w ten spos\u00f3b wytwarzaniu cAMP. Ponadto hamowane jest uwalnianie neuroprzeka\u017anik\u00f3w nocyceptywnych, takich jak substancja P, kwas gamma-aminomas\u0142owy (GABA), dopamina, acetylocholina i noradrenalina. Oksykodon hamuje r\u00f3wnie\u017c uwalnianie wazopresyny, somatostatyny, insuliny i glukagonu. Ponadto oksykodon zamyka bramkowane napi\u0119ciem kana\u0142y wapniowe typu N i otwiera zwi\u0105zane z bia\u0142kiem G kana\u0142y potasowe, wewn\u0119trznie naprawiaj\u0105c kana\u0142y potasowe, co powoduje hiperpolaryzacj\u0119 i zmniejszenie pobudliwo\u015bci neuron\u00f3w.<\/p>\n
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