Oxycodon ist ein halbsynthetisches morphin\u00e4hnliches Opioid-Alkaloid mit analgetischer Wirkung. Oxycodon \u00fcbt seine analgetische Wirkung durch Bindung an Mu-Rezeptoren im zentralen Nervensystem (ZNS) aus und ahmt damit die Wirkung endogener Opioide nach. Die Bindung an den Opiatrezeptor stimuliert den Austausch von GTP gegen PDB im G-Protein-Komplex und hemmt die Adenylatzyklase, wodurch die cAMP-Produktion verhindert wird. Au\u00dferdem wird die Freisetzung von nozizeptiven Neurotransmittern wie Substanz P, Gamma-Aminobutters\u00e4ure (GABA), Dopamin, Acetylcholin und Noradrenalin gehemmt. Oxycodon hemmt auch die Freisetzung von Vasopressin, Somatostatin, Insulin und Glucagon. Dar\u00fcber hinaus schlie\u00dft Oxycodon spannungsabh\u00e4ngige Kalziumkan\u00e4le vom N-Typ und \u00f6ffnet G-Protein-gebundene Kaliumkan\u00e4le, die intern Kaliumkan\u00e4le reparieren, was zu einer Hyperpolarisation und einer verringerten neuronalen Erregbarkeit f\u00fchrt.<\/p>\n
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